Our patient’s clinical course suggests that high doses of B vitamins (FA/folate and vitamin Bseveral) may modulate the course of PSA failure in castrate-resistant/refractory prostate cancer. Our patient’s ingestion of large amounts of FA/folate and vitamin B12 was associated with PSA acceleration, while withdrawal of the supplements was associated with a significant PSA decline. Whether this result was secondary to the perturbation of the outlined metabolic interactions of B vitamers (Figure 2), due to DNA epimethylation with associated changes in gene expression, or due to other factors is unknown. The hypothesis of a yet to be discovered interaction with docetaxel is entertained as well. Studies of patient use of health store supplements, many of which are known to affect DNA metabolism and DNA methylation markers, have revealed that up to 50% of cancer patients ingest large doses of vitamins and other supplements, such as probiotics, which contain “safe” bacteria that generate copious amounts of folates within the bowel. A recent study in our clinic revealed that a majority of cancer patients present with hypervitaminosis or hypovitaminosis of at least one or more of the B vitamins noted in Figure 2. As we have discussed herein, castration, drugs, diet, vitamin supplements, and probiotics may modulate tumor cell metabolism as well as gene expression by epimethylation and synthesis of DNA. We are concerned about the finding that many gas stations and liquor stores in the USA sell so-called “quick energy” liquid supplements that contain large amounts of B vitamins, including vitamins B6 and B12 and FA. Continue reading “Once i read of your dating off large volumes of folate so you’re able to broadening PSA, I instantly avoided bringing the enhance”
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